Anti-cAMP responsive element modulator (CREM) is encoded by the gene mapped to human chromosome 10p11.21. The encoded protein has tissue specific expression and it belongs to the family of cAMP-responsive promoter element (CRE)-binding factors. CREM contains 3'-located bZIP DNA-binding domains (DBD), kinase-inducible domain (KID) and two glutamine-rich domains.
Synonyms: Anti-cAMP-responsive element modulator antibody produced in rabbit
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: cAMP response element modulator (CREM) is a transcriptional factor belonging to the family of cAMP responsible factors. Upon alternative splicing and internal initiation of translation it produces transcriptional activators (CREMt) and repressors (CREMa, CREMb, CREMg, and S-CREM). It possesses sequence homology with CREB, a transcriptional activator. It couples with CREB to form CREM-CREB complex, and bind to the -180 site of the IL-2 (interlukin-2) promoter in anergic and systemic lupus erythematosus T cells.
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