CREB3L2 (cAMP responsive element binding protein 3-like 2) is also called BBF2 human homolog on chromosome 7 (BBF2H7), and along with old astrocyte specifically induced substance (OASIS) is a member of the cAMP response element-binding protein (CREB)/ATF (Activating transcription factor) family. It is a transmembrane protein, and acts as a bZIP (basic leucine zipper) transcription factor. This gene has 12 exons, and covers >120kbp. It has a transactivation region in its N-terminal, a leucine zipper, a DNA-binding domain, a transmembrane a-helical hydrophobic region, and a luminal domain. It is an endoplasmic reticulum (ER) protein, but an alternatively spliced variant is found in both ER and nucleus.
Synonyms: Anti-BBF2 human homolog on chromosome 7; Anti-cAMP-responsive element-binding protein 3-like protein 2
Storage: -20C
Application: Anti-CREB3L2 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: CREB3L2 (cAMP responsive element binding protein 3-like 2) confers protection during endoplasmic reticulum (ER) stress, and in response to ER stress is cleaved in its transmembrane region. It regulates the transcription of Sec23A, when it acts like a bZIP transcription factor. This is essential for collagen synthesis in dermal fibroblasts, where it ensures the proper trafficking of procollagen from ER-to-Golgi. It is a fusion partner of FUS gene in low-grade fibromyxoid sarcoma (LGFMS), and this fusion forms a supernumerary ring chromosome, which is related to tumor progression. It is a substrate for F-box and WD repeat domain-containing-7 (Fbxw7) protein, and is degraded by the same. This process, in turn, regulates osteogenesis and chondrogenesis. It also acts as a fusion partner of PPAR (Peroxisome proliferator-activated receptor) ? in thyroid carcinoma, and this fusion inactivates a thyroid signaling pathway.
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