The gene CRBN (cereblon) is mapped to human chromosome 3p26.2. It is strongly expressed in the brain. The encoded protein has a conserved Lon (ATP-dependent protease La) domain. The CRBN protein is present in the cytoplasm and nucleus.CRBN protein interacts with:
•DDB1 (anti-DDB1 HPA068456)
•SLC16A1 (anti-SLC16A1 HPA071055)
•BSG (anti-BSG HPA036048)
•PSMB4 (anti-PSMB4 HPA006700)
•PRKAA1 (anti-PRKAA1 HPA064946)
Synonyms: Anti-MRT2; Anti-MRT2A
Storage: -20C
Application: Anti-CRBN antibody produced in rabbit has been used in immunohistochemistry
Biochem Physiol Actions: CRBN (cereblon) mainly recruits substrates for E3 ubiquitin ligase. It interacts with BKCa (calcium-activated potassium channel subunit a-1), ClC-2 (chloride channel protein 2), AMPK (5'-AMP-activated protein kinase), PSMB4 (proteasome subunit ß 4), ikaros (IKZF1), aiolos (IKZF3) and MEIS2 (Meis1-related protein). These interactions might be required for sending the proteins for ubiquitination by the E3 ubiquitin ligase. Degradation of IKZF1 (ikaros family zinc finger protein 1) and IKZF3 by lenalidomide (immunomodulatory drug)-bound CRBN helps in anti-myeloma effect of lenalidomide. Similarly, treatment with thalidomide in CRBN positive cells is effective in elderly patients with multiple myeloma. CRBN might also be associated with autosomal recessive nonsyndromic intellectual disability.
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