Collagen type I alpha 1 chain (COL1A1) gene is located on the human chromosome at 17q21.33. It encodes the proa1 chain of type I procollagen. COL1A1 is found extensively in mammals and is the main structural protein present in teeth, bones and tendons.
Synonyms: Anti-Alpha-1 type I collagen; Anti-Collagen alpha-1(I) chain precursor
Storage: -20C
Application: Anti-COL1A1 antibody produced in rabbit has been used in western blotting and immunofluorescence.
Biochem Physiol Actions: Collagen type I alpha 1 chain (COL1A1) plays a role in bone strength, which is measured as bone mineral density. Mutations in COL1A1 along with COL1A2 are associated with osteogenesis imperfecta (OI), which results in decreased production of collagen type I.
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