COL17A1 (collagen XVII) is a member of the collagen family. It is an essential component of the hemidesmosome structure. COL17A1 is present in the Bowman layer and around the epithelial cells. It consists of an intracellular globular domain, a transmembrane segment and an extracellular domain. COL17A1 has 56 distinct exons and is mapped to human chromosome 10.
Synonyms: Anti-BP180; Anti-BPAG2; Anti-Collagen, Type XVII, Alpha 1
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: COL17A1 (collagen XVII) helps in anchoring corneal epithelial cells to the epithelial basement membrane. Mutations in COL17A1 results in junctional epidermolysis bullosa (JEB). It also plays an important role in hair thinning.
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