CNP (2',3'-cyclic nucleotide 3' phosphodiesterase) is highly expressed in brain and is used as a marker for oligodendrocytes. It is a member of the 2H phosphoesterase superfamily. The gene is mapped to human chromosome 17q.
Synonyms: Anti-2',3'-cyclic-nucleotide 3'-phosphodiesterase; Anti-CNP; Anti-CNPase
Storage: -20C
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Biochem Physiol Actions: CNP (2',3'-cyclic nucleotide 3' phosphodiesterase) is responsible for the conversion of 2',3'-cAMP (cyclic adenosine monophosphate) to 2'-AMP. It also plays a crucial role in the renal 2',3'-cAMP-adenosine pathway. It is needed for the outgrowth in oligodendrocytes and association with microtubules, cytoskeleton, and RNA. Upon aging, low expression of CNP is associated with a catatonia-depression syndrome in humans. CNP also participates in the interferon-mediated suppression of HIV (human immunodeficiency virus) and HBV (hepatitis B virus) production.
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