CNP (2',3'-cyclic nucleotide 3' phosphodiesterase) is highly expressed in brain and is used as a marker for oligodendrocytes. It is a member of the 2H phosphoesterase superfamily. The gene is mapped to human chromosome 17q.
Synonyms: Cnp Antibody; Cnp Antibody - Anti-CNP antibody produced in rabbit; Anti-2',3'-cyclic-nucleotide 3'-phosphodiesterase; Anti-CNP; Anti-CNPase
Storage: -20C
Application: Anti-CNP antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: CNP (2',3'-cyclic nucleotide 3' phosphodiesterase) is responsible for the conversion of 2',3'-cAMP (cyclic adenosine monophosphate) to 2'-AMP. It also plays a crucial role in the renal 2',3'-cAMP-adenosine pathway. It is needed for the outgrowth in oligodendrocytes and association with microtubules, cytoskeleton, and RNA. Upon aging, low expression of CNP is associated with a catatonia-depression syndrome in humans. It also participates in the interferon-mediated suppression of HIV (human immunodeficiency virus) and HBV (hepatitis B virus) production.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC