Claudin-1 (CLDN1), also called senescence-associated epithelial membrane protein (SEMP1), is a component of tight junctions strands. It is 22 kDa protein and has four transmembrane strands. CLDN1 gene is mapped to human chromosome 3q28.
Synonyms: Anti-ILVASC; Anti-SEMP1
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Claudin-1 (CLDN1) plays a key role in the tight junction barrier formation. It interacts with claudin-3 and modulates tight junctions in human airway epithelium. CLDN1 acts as a receptor for the hepatitis C virus entry and participates in the internalization of the virus. Mutation in CLDN1 gene is implicated in ichthyosis and neonatal sclerosing cholangitis (NISCH syndrome). CLDN1 is highly expressed in colon cancer.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC