Claudin-5, a transmembrane protein deleted in velo-cardio-facial syndrome (TMVCF), seems to be involved in endothelial tight junctions. Claudin-5 has been exclusively found in the cell-cell borders of endothelial cells. Lower claudin-5 levels in sinusoidal endothelial cells could lead to their dysfunction during liver injuries. Levels of claudin-5 in tumor vessels could be a potential marker for hepatocellular carcinoma prognosis. The loss of claudin-5 function has been linked to carcinogenesis.
Synonyms: Claudin-5, Transmembrane protein deleted in VCFS, TMDVCF
Storage: 2-8C
Application: Research Sub CategoryAdhesion (CAMs)
Other Notes: Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.