CHL1 (cell adhesion molecule L1-like) is also called as CALL (cell adhesion L1-like) and is expressed in normal tissues, brain, and a variety of human cancer cell lines and primary tumor tissues. The gene is mapped to human chromosome 3p26.3.
Synonyms: Anti-Close homolog of L1 antibody produced in rabbit; Anti-Neural cell adhesion molecule L1-like protein precursor antibody produced in rabbit
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: CHL1 (cell adhesion molecule L1-like) gene encodes a one-pass trans-membrane protein belonging to the L1 gene family of neural cell adhesion molecules. The protein is capable of both homotypic and heterotypic binding and may be involved in signal transduction pathways. The gene has been implicated in cancer growth and metastasis and some neurological diseases such as schizophrenia. It also functions in general cognitive activities. Deletion of one copy of this gene causes mental defects in patients with 3p- syndrome. It may serve as a potential biomarker in the early pathogenesis of two major histological types of renal cancer. Deficiency of this protein is found to promote tumor formation and it overexpression suppresses proliferation and invasion. It may be a potential therapeutic target for breast carcinogenesis and progression.
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