CHEK1 is a serine/threonine kinase that functions as a sensor for the stress response pathway in cells. It is activated by ATR kinase phosphorylation in response to DNA damage, and can subsequently modulate p53 phosphorylation. CHEK1 activity is inhibited by BCL6 in B cells.Rabbit Anti-CHEK1 antibody recognizes zebrafish, bovine, chicken, human, mouse, rat, and canine CHEK1.
Synonyms: Anti-CHK1 checkpoint homolog (S. pombe)
Storage: -20C
Application: Rabbit Anti-CHEK1 antibody can be used for western blot applications at a concentration of 0.5mug/ml. It can also be used for immunohistochemistry at 4-8mug/ml.
Biochem Physiol Actions: CHEK1 is required during normal S phase to avoid aberrantly increased initiation of DNA replication, thereby protecting against DNA breakage. Its expression is dispensable for somatic cell death and critical for sustaining G2 DNA damage checkpoint.