Cyclic GMP-AMP synthase (cGAS), also known as cGAMP synthase, h-cGAS, Mab-21 domain-containing protein 1, and encoded by the gene name MB21D1 and C6orf150, is a member of the MAB-21 family. Cyclic GMP-AMP synthase (cGAS) is a nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. The catalysis process involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Recent studies have indicated that Cyclic GMP-AMP synthase (cGAS) has an antiviral activity by acting as a key cytosolic DNA sensor, when the presence of double-stranded DNA (dsDNA) in the cytoplasm acts as a danger signal that triggers the immune responses. Cyclic GMP-AMP synthase (cGAS) then binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. Cyclic GMP-AMP synthase (cGAS) is expressed in the monocytic cell line THP1.
Synonyms: Cyclic GMP-AMP synthase, cGAMP synthase, cGAS, h-cGAS, Mab-21 domain-containing protein 1
Application: This Anti-cGAS antibody is validated for use in Western Blotting for the detection of cGAS.
Other Notes: Concentration: Please refer to lot specific datasheet.