The gene CDK11A (cyclin dependent kinase 11A) is mapped to human chromosome 1p36.33. Human genome contains two genes for CDK11, CDK11A and CDK11B. Both genes have three isoforms, the long CDK11p110, short CDK11p58 and CDK11p46. CDK11p110 is present in the nucleus, CDK11p58 is present in the nucleus and cytoplasm, and CDK11p46 is in the cytoplasm. CDK11p58 is mainly expressed in the G2/M phase. CDK11p110 is expressed during the whole cell cycle. The CDK11A protein has many NLSs (nuclear localization sequences), a 14-3-3 consensus site, an arginine/glutamic acid domain (RE domain), a poly-glutamic acid domain (poly-E domain) and a carboxy-terminal catalytic domain.
Synonyms: Anti-CDC2L2; Anti-CDK11; Anti-Cell division cycle 2-like protein kinase 2; Anti-Galactosyltransferase-associated protein kinase p58/GTA; Anti-PITSLRE serine/threonine-protein kinase CDC2L2
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: CDK11 (cyclin dependent kinase 11) regulates transcription and RNA processing (mainly alternate splicing) by binding to L-type cyclins. It is also involved in cellular responses, such as hormone receptor signaling and autophagy. CDK11p58 is needed for duplication of the centrioles, spindle rearrangement and sister chromatid cohesion at centromeres. CDK11 plays an important role in cancer cell growth and proliferation by regulating cell death.
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