CDC42EP4 (CDC42 effector protein 4) belongs to the BORG (binder of Rho GTPases) family of proteins. It is widely expressed and the gene is mapped to human chromosome 17q24-25.
Synonyms: Anti-BORG4; Anti-CDC42 effector protein (Rho GTPase binding) 4; Anti-CEP4; Anti-KAIA1777; Anti-LYC1; Anti-MGC17125; Anti-MGC3740; Anti-PRO1485; Anti-TKAL754
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: CDC42EP4 (CDC42 effector protein 4) binds to CDC42 (cell division cycle 42). In the cerebellum, it associates with septin hetero-oligomers. The association is needed for the perisynaptic localization of GLAST (sodium-dependent glutamate/aspartate transporter 1) and for the efficient glutamate-buffering. In NIH-3T3 fibroblasts, CDC42EP4 is also involved in pseudopodia formation.
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