CD74 (cluster of differentiation 74) is the invariant chain of MHC (major histocompatibility) complex class II. It was the first receptor to be recognized for macrophage migration inhibitory factor (MIF). It is a membrane receptor.
Synonyms: Anti-CD74 antigen antibody produced in rabbit; Anti-HLA class II histocompatibility antigen gamma-chain antibody produced in rabbit; Anti-HLA-DR antigens-associated invariant chain antibody produced in rabbit; Anti-Ia antigen-associated invariant chain antibody produced in rabbit; Anti-Ii antibody produced in rabbit; Anti-p33 antibody produced in rabbit
MDL Number: MFCD00212292
Storage: -20C
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Biochem Physiol Actions: CD74 (cluster of differentiation 74) acts as the chaperone of MHC-II (major histocompatibility) and is responsible for the trafficking of MHC-II molecules in APCs (antigen presenting cells). It also interacts with non-MHC proteins and functions as a receptor for MIF (macrophage migration inhibitory factor). MIF is a pleiotropic cytokine having pro-tumorigenic and pro-inflammatory functionality. It is involved in the progression and metastasis of hematologic and solid cancers, and its up-regulation in thyroid cancer might be linked with advanced tumor stage. In patients with malignant pleural mesothelioma, the over-expression of this protein functions as an independent prognostic marker for overall survival.
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