Synonyms: DKFZp686M18236; GP110; SCARD1
MDL No.: MFCD00240656
Storage: -20C
UNSPSC Code: 12352203
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General description: This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. (provided by RefSeq)
Biochem/physiol Actions: CD68 (Cluster of Differentiation 68), a scavenger receptor, significantly participates in the development of Alzheimer′s disease. CD68 serves as a prognostic marker in tumor cells. Deletion of the gene is known to cause reduction in the bone resorption capacity.
Immunogen: CD68 (NP_001242.2, 1 a.a. ~ 354 a.a) full-length human protein.SequenceMRLAVLFSGALLGLLAAQGTGNDCPHKKSATLLPSFTVTPTVTESTGTTSHRTTKSHKTTTHRTTTTGTTSHGPTTATHNPTTTSHGNVTVHPTSNSTATSQGPSTATHSPATTSHGNATVHPTSNSTATSPGFTSSAHPEPPPPSPSPSPTSKETIGDYTWTNGSQPCVHLQAQIQIRVMYTTQGGGEAWGISVLNPNKTKVQGSCEGAHPHLLLSFPYGHLSFGFMQDLQQKVVYLSYMAVEYNVSFPHAAQWTFSAQNASLRDLQAPLGQSFSCSNSSIILSPAVHLDLLSLRLQAAQLPHTGVFGQSFSCPSDRSILLPLIIGLILLGLLALVLIAFCIIRRRPSAYQAL
Physical form: Solution in phosphate buffered saline, pH 7.4
RIDADR: NONH for all modes of transport