Myeloid cell surface antigen CD33 (cluster of differentiation 33), also known as SIGLEC3 (sialic acid binding Ig-like lectins) and GP67, belongs to the CD33-related SIGLEC gene family. It is a type 1 transmembrane protein and has two immunoglobulin-like extracellular domains, a single transmembrane area and two intracellular inhibitory motifs. The CD33 gene is located on human chromosome 19q13.
Synonyms: Anti-FLJ00391; Anti-SIGLEC-3; Anti-SIGLEC3; Anti-p67
Storage: -20C
Application: Anti-CD33 antibody has been used in immunohistochemical staining.
Biochem Physiol Actions: CD33 (cluster of differentiation 33) is mainly involved in anti-inflammatory signaling, cell adhesion and endocytosis functions. CD33 serves as a myeloid differentiation marker. Mutations in the CD33 gene are associated with Alzheimer's disease susceptibility and acute myeloid leukemia treatment efficacy.
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