CCNB2 (cyclin B2) is localized to human chromosome 15q22.2. This protein belongs to the three-member protein family called cyclin B, which also includes cyclin B1 and cyclin B3. It shares high homology to cyclin B1, and resides in the Golgi apparatus.
Synonyms: Anti-G2/mitotic-specific cyclin-B2 antibody produced in rabbit
Storage: -20C
Application: Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Immunohistochemistry (1 paper)
Biochem Physiol Actions: CCNB2 (cyclin B2) activates CDC2 kinase, and thus, facilitates G2/M transition during cell cycle. This protein is up-regulated in colorectal adenocarcinoma, lung cancer and pituitary adenomas. In node-negative breast tumors it is linked with poor prognosis. Therefore, it functions as an oncogene and might be responsible for enhanced proliferation. In patients with non-small cell lung cancer, the up-regulation of this protein is linked with poor prognosis.
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