CBX5 (chromobox homolog 5) is a chromosomal protein consisting of a N-terminal chromodomain and a C-terminal chromo shadow domain connected with an unstructured hinge region.
Synonyms: Anti-Antigen p25; Anti-Chromobox protein homolog 5; Anti-HP1 alpha; Anti-Heterochromatin protein 1 homolog alpha
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: CBX5 (chromobox homolog 5) is involved in the regulation of DNA mediated cellular processes such as DNA damage repair, chromatin plasticity, centromere dynamics, and transcription promoting accurate cell division. It plays a vital role in assembly of chromatin structures by directly binding to lysine 9-methylated histone H3 (H3K9me), a hallmark of heterochromatin. Before binding, it identifies the histone dimethylation and trimethylation of Lys-9 via its chromodomain.
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