Synonyms: Anti-Core-binding factor, runt domain, alpha-subunit 2; translocated to 3
Storage: -20C
Biochem Physiol Actions: The t(16;21)(q24;q22) translocation is a rare but recurrent chromosomal abnormality associated with therapy-related myeloid malignancies. The translocation produces a chimeric gene made up of the 5'-region of the AML1 gene fused to the 3'-region of CBFA2T3. In addition, CBFA2T3 is a putative breast tumor suppressor.