Cell cycle associated protein 1 (CAPRIN1) gene is mapped to human chromosome 11p13. The gene codes for highly conserved cytoplasmic phosphoprotein. CAPRIN1 belongs to the conserved caprin family. The protein is ubiquitously expressed and is characterized with two highly conserved regions, homologous region-1 and -2, arginine-glycine-glycine (RGG) motif and the RG enrichment region.
Synonyms: Anti-Caprin-1; Anti-Cell cycle associated protein 1; Anti-Cytoplasmic activation- and proliferation-associated protein 1; Anti-GPI-anchored membrane protein 1; Anti-GPI-anchored protein p137; Anti-GPI-p137; Anti-p137GPI
Storage: -20C
Application: Anti-CAPRIN1 antibody produced in rabbit has been used in immunohistochemistry (IHC) and western blotting.
Biochem Physiol Actions: Cell cycle associated protein 1 (CAPRIN1) is associated with cell proliferation and is essential for normal advancement through the G1-S phase of the cell cycle. It is involved in the formation of stress granules via phosphorylation of eIF2a (a transcription initiation factor) and also regulates the translation of mRNAs of proteins related to synaptic plasticity in neurons. Studies have shown that Japanese encephalitis virus (JEV) causes a translational shutoff by preventing the formation of stress granules through interaction of JEV core protein with CAPRIN1. It has also been shown that it may be involved in the development of osteosarcoma.
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