Calnexin is a Ca++ binding protein found in ER transmembranes that binds to specific n-linked oligosaccharides found on newly synthesized proteins. Calnexin associates with the ER membrane phosphoglycoprotein, signal sequence receptor SSRmu, and has been identified as the ER protein associated with major histocompatibility complex (MHC) class I heavy chain and with the T-cell receptor and membrane immunoglobulin before assembly of these multimeric complexes. Hence, calnexin may represent a molecular chaperone in the ER membrane that is selective for incompletely folded oligomeric membrane proteins newly translocated to the ER.
Synonyms: Calnexin, IP90, Major histocompatibility complex class I antigen-binding protein p88, p90
Application: Research Sub CategoryDevelopmental Neuroscience
Other Notes: Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.