CALB1 (calbindin 1) is a member of the EF-hand family of calcium-binding proteins. It is mainly present in the cerebellum. The gene is mapped to human chromosome 8q21.
Synonyms: Anti-Calbindin; Anti-Calbindin D28; Anti-D-28K; Anti-Vitamin D-dependent calcium-binding protein, avian-type
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: CALB1 (calbindin 1) participates in the Ca2+-dependant activities occuring in CALB1-expressing neurons. It is associated with the activation and maintenance of long term depression (LTD). It provides neuroprotection in the presence of oxidative stress. In mice model, absence of CALB1 causes severe neurological and behavioral disorders. Low expression of CALB1 is also linked with the cognitive abnormalities observed with MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes).
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC