CA12 (carbonic anhydrase XII) gene is localized to human chromosome 15q22. This gene is predominantly expressed in adult pancreas, colon, kidney and prostate. It belongs to a CA gene family, and is composed of a leader sequence, an a CA domain, a transmembrane region and a short cytoplasmic domain.
Synonyms: Anti-CA-XII antibody produced in rabbit; Anti-Carbonate dehydratase XII antibody produced in rabbit; Anti-Carbonic anhydrase 12 precursor antibody produced in rabbit; Anti-Carbonic anhydrase XII antibody produced in rabbit; Anti-Tumor antigen HOM-RCC-3.1.3 antibody produced in rabbit
Storage: -20C
Application: Anti-CA12 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: CA12 (carbonic anhydrase XII) catalyzes the hydration of CO2 generated by cells into bicarbonate and protons. Expression of this enzyme in oral squamous cell carcinoma (OSCC) is related to tumor progression and poor prognosis. The expression levels of this enzyme are also linked to the histological grade of cervical cancer, and absence of its expression correlates with poorly differentiated phenotype. The presence of this enzyme marginally links with better disease-free survival of cervical cancer patients.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC