Complement component 3 (C3) is the key component of the complement system. It is referred to as ASP, C3a, C3ß, AHUS5, ARMD9, CPAMD1 and HEL-S-62p. C3 is acted upon by C3 convertases, which produces the activated C3b. It is a member of the a2-macroglobulin protein family. It possesses an a- and ß-chain of 115 and 75kDa respectively. These together form 13 domains. These domains are divided into single linker (LNK), anaphylatoxin (ANA/C3c), C1r/C1s-UEGF-BMP1 (CUB), C345c and thioester-containing domains (TED), namely eight macroglobulin domains (MG1-MG8).
Synonyms: Anti-ARMD9; Anti-C3a; Anti-C3b; Anti-CPAMD1
MDL Number: MFCD02685984
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Complement component 3 (C3) is a key fluid-phase protein of the immune system. Complement activation of this gene results in the formation of multiple C3b plasma protein complexes in serum. It helps in recognizing and tags damaged plasma proteins for subsequent removal from the blood without triggering pro-inflammatory functions. The C3 serum levels are associated with angiographic parameters of atherosclerosis.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC