C2CD2L (C2 domain containing protein 2 like) is a type I transmembrane protein, which has its C-terminal facing the cytosol and the N-terminal projecting into the lumen. This gene maps to human chromosome 11q23.3, and is expressed predominantly in the pancreatic islets. It also contains a C2 domain, and shows similarity to synaptotagmin.
Synonyms: Anti-C2CD2-like; Anti-KIAA0285; Anti-TMEM24
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: C2CD2L (C2 domain containing protein 2 like) is found in the pancreatic islets, and controls the release of insulin from granules, in response to glucose. It aids in the exocytosis of insulin granules and synaptic vesicles in a Ca2+-dependent manner. As different granules have different Ca2+ responsiveness, C2CD2L maintains glucose homeostasis by modulating insulin release.
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