Synonyms: Anti-BTF3; Anti-BTN3.3
Storage: -20C
Application: Anti-BTN3A3 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: BTN3A3 (butyrophilin, subfamily 3, member A3) gene encodes a member of the butyrophilin (BTN) family, the members of which are major histocompatibility complex (MHC)-associated genes. These genes encode type I membrane proteins containing two extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. BTN3A3 is expressed on endothelial cells, in the membrane layer surrounding milk fat-secreting droplet from mammary epithelial cells, on immune cells, and on some tumor cell lines. It may be involved in the proliferation of CD4+ and CD8+ and in the cytokine secretion by T-cells. It may function as a co-stimulatory molecule on CD4+ T cells and NK (Natural Killer) cells.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC