Anti-ß-Catenin antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the 15B8 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a BALB/c mouse immunized with recombinant chicken ß-Catenin. ß-Catenin, also known as Catenin ßfamily.
Synonyms: Anti-CTNNB1; Anti-armadillo
Storage: -20C
Application: Anti-beta-Catenin antibody, Mouse monoclonal has been used in:
•immunoblotting
•immunofluorescence
•immunohistochemistry
•immunoprecipitation
Biochem Physiol Actions: ß-Catenin plays a dual function in the cell including cell-cell adhesion and as a component of the Wnt (wingless) signaling pathway. In adherens junctions, ß-Catenin associates with the cytoplasmic domain of the cadherin family adhesion receptors, anchoring them to the actin cytoskeleton and thus acting as structural protein. ß-Catenin interacts with T cell factor (TCF)- family transcription factors to activate target genes. Wnt/ß-catenin signaling interacts with several cellular pathways in context-dependent ways, including JakSTAT (Janus kinase-Signal transducer and activator of transcription) cytokine, TGFß (transforming growth factor-ß), DNA damage and the Hippo signaling pathways. Furthermore, ß-Catenin is involved in embryonic morphogenesis and tumorigenesis and is tightly regulated by phosphorylation and further degradation by the ubiquitin-proteasome system.