The ß-amyloid precursor protein (APP) is cleaved sequentially by the proteolytic enzymes ß-secretase (BACE1) and ?-secretase to produce ß-amyloid (Aß) peptides with the Aß1-42 and the Aß1-40 forms being the most prevalent. Secreted Aß peptides are degraded either via a re-uptake mechanism followed by endosomal degradation, or by an extracellular insulin degrading enzyme. Extracellular accumulation of Aß leads to the formation of aggregates, fibrils and eventually amyloid deposits called neuritic plaques, which is the hallmark of Alzheimer's disease (AD).Monoclonal Anti ß-Amyloid [13-28] recognizes the ß-Amyloid peptide. The antibody epitope resides within amino acids 20-23.
Synonyms: Anti-Abeta
MDL Number: MFCD07370937
Storage: -20C
Application: Mouse Monoclonal Anti-ß-Amyloid (13-28) antibody can be used for immunoblotting assays at 1:5,000. The antibody can also be used for IHC, immunoprecipitation,fluorescence infrared spectroscopy and enzyme immunoassays (02-0.4µg/ml).