Bcl-2-related protein A1 (BCL2A1), also known as protein BFL-1, protein GRS, and Bcl-2-like protein 5 (Bcl2-L-5), is a member of the Bcl-2 family. BCL2A1/BFL-1 can interact with Bax and suppress apoptosis by inhibiting the release of cytochrome c and caspase-3 activation. BCL2A1/BFL-1 is expressed in peripheral blood, spleen, bone marrow, lung, small intestine, and testis.
Synonyms: Bcl-2-related protein A1, Bcl-2-like protein 5, Bcl2-L-5, Hemopoietic-specific early response protein, Protein BFL-1, Protein GRS
Application: Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected BCL2A1/BFL-1 in 0.2 µg of Jurkat cell lysate.Western Blotting Analysis: A representative lot detected BCL2A1/BFL-1 in human lymphoma cell lysate (Yecies, D., et al. (2010). Blood. 115(16):3304-13).Western Blotting Analysis: A representative lot detected BCL2A1/BFL-1 in chronic lymphocytic leukemia cell lysate (Natoni, A., et al. (2011). Mol Cancer Ther. 10(9):1624-1634).Immunohistochemistry Analysis: A representative lot detected BCL2A1/BFL-1 in lymph node tissue (Vogler, M., et al. (2009). Blood. 113(18): 4403-4413).Immunoprecipitation Analysis: A representative lot immunoprecipitated BCL2A1/BFL-1 in chronic lymphocytic leukemia cell lysate (Vogler, M., et al. (2009). Blood. 113(18): 4403-4413).