ß-site APP cleaving enzyme (BACE-1) is known as ß-secretase. It consists of an N-terminal signal peptide (SP), a pro-peptide (Pro) domain, a catalytic domain, a transmembrane domain and a C-terminal tail.
Synonyms: Anti-beta-Site APP-cleaving enzyme 1; Anti-ASP2; Anti-BACE; Anti-FLJ90568; Anti-HSPC104
MDL Number: MFCD03096637
Storage: -20C
Biochem Physiol Actions: ß-site APP cleaving enzyme (BACE-1) acts as a rate-limiting enzyme of amyloid-ß-peptide (Aß). Overexpression of BACE-1 leads to increased ß-secretase activity.