B4GALT1 (UDP-Gal:ßGlcNAc ß 1,4- galactosyltransferase, polypeptide 1) belongs to a family of type II transmembrane proteins called glycosyltransferases, which resides in Golgi apparatus. This family consists of seven members, from GALT1 to GALT7. B4GALT1 has two isoforms, having different cellular locations, because of differences in their cytoplasmic domains. The long isoform is localized to the cell surface, whereas the short isoform is found in the Golgi apparatus. This gene is located on human chromosome 9p13, and codes for a protein containing 398 amino acids. It is expressed in most tissues, excluding adult brain and fetal heart and brain.
Synonyms: Anti-beta-1,4-GalTase 1 antibody produced in rabbit; Anti-beta-1,4-Galactosyltransferase 1 antibody produced in rabbit; Anti-beta4Gal-T1 antibody produced in rabbit; Anti-UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1 antibody produced in rabbit; Anti-UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1 antibody produced in rabbit; Anti-b4Gal-T1 antibody produced in rabbit
Storage: -20C
Application: Anti-B4GALT1 antibody produced in rabbit has been used in immunofluorescence microscopyand immunoblotting.
Biochem Physiol Actions: B4GALT1 (UDP-Gal:ßGlcNAc ß 1,4- galactosyltransferase, polypeptide 1) is responsible for the synthesis of galactose ß-1,4-N-acetylglucosamine (Galß1-4GlcNAc) groups on glycoproteins, on their N-linked sugar chains. This is performed by the short isoform of B4GALT1, which resides in Golgi bodies. The long isoform, localized to the cell surface, helps in cell adhesion, by interacting with N-acetylglucosamine containing oligosaccharides, which are found in the extracellular matrix. In patients with rheumatoid arthritis, it is involved in the inflammatory response in the synovial tissue. B4GALT1 plays an important role in the proliferation of MCF-7 breast cancer cells by interacting with estrogen receptor. It is methylated and down-regulated in colorectal cancer patients, and hence, can act as a marker of invasive phenotype of colorectal cancer.
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