Autism susceptibility gene 2 (AUTS2) is a part of polycomb repressive complex 2 (PRC2). The gene is located on human chromosome 7q11.22. AUTS2 consists of two proline-rich regions (PR1 and PR2), eight histidine repeats, nuclear localizing sequences and one predicted PY motif. It is expressed in the brain.
Synonyms: Anti-Autism susceptibility gene 2 protein
Storage: -20C
Application: Anti-AUTS2 antibody produced in rabbit has been used in:
•immunohistochemistry
•immunoprecipitation
•immunofluorescence
•western blotting(10)
Biochem Physiol Actions: Autism susceptibility gene 2 (AUTS2) functions as a chromatin modulator, which regulates early lymphoid development and T-cell leukemogenesis. It is associated with autism, alcoholism and heroin dependence. AUTS2 alters Rac signaling. Mutations in this gene is associated with autism spectrum disorders (ASDs), developmental delay and intellectual disability. AUTS2 is implicated in cytoskeleton regulation, transcriptional regulation and neural development.
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