ATP6V1G3 (ATPase, H+ transporting, lysosomal, V1 subunit G3) belongs to the V1 sector of V-ATPase (vacuolar H+ ATPase). It encodes a constituent of vacuolar proton-pumping ATPase. Its expression is restricted to the kidney and inner ear.
Synonyms: Anti-ATP6G3; Anti-ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3; Anti-Vma10
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: ATP6V1G3 (ATPase, H+ transporting, lysosomal, V1 subunit G3) plays a major role in differentiating between chromophobe RCC (renal cell carcinoma) and other subtypes of RCC. Vacuolar proton-pumping ATPase containing ATP6V1G participates in organelle and synaptic vesicle acidification. It is a highly delicate and particular immunohistochemical marker for chromophobe RCC (renal cell carcinoma) and oncocytoma.
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