Synonyms: Anti-ASB-8; Anti-Ankyrin repeat and SOCS box protein 8
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: ASB8 (ankyrin repeat and SOCS box containing 8) gene encodes a protein belonging to the ankyrin repeat and SOCS (suppressor of cytokine signaling) box containing protein family. It contains four Ankyrin repeats and one SOCS box. The gene contains four exons interspaced by three introns is mapped to chromosome 12q13. It is predominantly expressed in skeletal muscle and at varied levels in heart, brain, placenta, liver, kidney, and pancreas. It may be involved in the development of lung cancer. It may be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex that functions in ubiquitination and proteasome-mediated degradation of target proteins.
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