SH3 domain-containing guanine exchange factor (ARHGEF26) is a Rho (a GTPase) guanine exchange factor. It is expressed in many cell lines and strongly expressed in liver tissue. ARHGEF26 is an 871-amino acid protein with an amino-terminal region, a DbI homology (DH) domain and a carboxyl-terminal SH3 domain. The gene encoding this protein is located on chromosome 3q25.2.
Synonyms: Anti-AC018452.11; Anti-RP11-23D24.1; Anti-SH3 domain-containing guanine exchange factor
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: SH3 domain-containing guanine exchange factor (ARHGEF26) promotes epidermal growth factor receptor (EGFR) stability and epidermal growth factor (EGF)-induced extracellular signal-regulated kinase (ERK1/2) activation. It binds with growth factor receptor-bound protein 2 (Grb2) which is a downstream transducer of EGFR. In fibroblasts, ARHGEF26 induces the formation of interconnected cell ruffles with actin polymerization across dorsal surfaces. It colocalizes with filamentous actin at the sites where membrane protrusion has occurred. Overexpression of ARHGEF26 has been linked to prostate cancer progression.
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