HMHA1 (Histocompatibility minor HA-1) is an autosomal minor H antigen consisting of RhoGTPase activating protein (GAP) domain at the C-terminal end and a Bin/Amphiphysin/Rvs (BAR) domain at the N-terminal end. It is located on chromosome 19p13.3. It is mainly expressed in hematopoietic system, comprising normal and leukemic cells, including progenitor cells.
Synonyms: HA-1; HMHA1; KIAA0223
Storage: -20C
Application: Anti-HMHA1 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: HMHA1 (Histocompatibility (minor) HA-1) acts as a novel RhoGAP factor involved in the regulation of actin cytoskeleton organization. It is associated with several essential functions in normal hematopoietic and cancer cells GTPase activity, cytoskeletal remodelling and cell spreading.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC