Rho GTPase activating protein 32 (ARHGAP32) is encoded by the RICS gene mapped to human chromosome 11q24.3. RICS exists in two isoforms; RICS is expressed specifically in the brain in humans, whereas, PX-RICS is expressed in several tissues but at high levels in the brain. PX-RICS is characterized by a N-terminal src homology 3 (SH3) and a phox-homology (PX) domain mainly involved in binding phosphatidylinositol-4-phosphate (PI4P).
Synonyms: Anti-GC-GAP; Anti-GRIT; Anti-KIAA0712; Anti-MGC1892; Anti-RICS; Anti-Rho GTPase activating protein 32
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Rho GTPase activating protein 32 (ARHGAP32)/RICS, is a GTPase-activating protein that plays a vital role in the maintenance of dendritic spine morphology and strength by regulating Rho GTPases. Mutation in the gene leads to alexithymia. ARHGAP32 plays a crucial role in the regulation of various neural functions, including postsynaptic N-methyl-D-aspartate (NMDA) signaling and neurite outgrowth.
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