Adipocyte plasma membrane-associated protein (APMAP) is a member of the lactonohydrolase super family. It is a 416 amino acid, glycosylated membrane-bound protein. APMAP is expressed in the liver, placenta and kidney. It has an N-glycosylation site, an extracellular carboxyl-terminal domain and a transmembrane segment. The gene encoding this protein is located on chromosome 20.
Synonyms: Anti-Adipocyte plasma membrane-associated protein; Anti-BSCv protein; Anti-C20orf3
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Adipocyte plasma membrane-associated protein (APMAP) plays an important role in adipocyte differentiation. The carboxyl-terminal domain helps for this function. It acts as a suppressor of amyloid-ß generation. It has been shown that APMAP interacts with ?-secretase and its substrate. APMAP has been shown to be involved in hepatic-specific metastasis in metastatic colorectal cancer (CRC).
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