Apex2 (apurinic/apyrimidinic endodeoxyribonuclease 2) is located in the nucleus and also to some extent to the mitochondria. It belongs to the novel AP endonuclease family with a mitochondrial targeting sequence (MTS) and proliferating cell nuclear antigen (PCNA)-binding motif. APEX2 is located on human chromosome Xp11.21 and has six exons.
Synonyms: APE2; APEXL2; XTH2; ZGRF2
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Apex2 (apurinic/apyrimidinic endodeoxyribonuclease 2) maintains the function and integrity of mitochondrial DNA. It possesses a robust 3'-5' exonuclease activity. Ape2 helps to delete adenine opposite to 8-oxoG in DNA.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC