AOC1 (amine oxidase, copper containing 1) is mapped to human chromosome 7q36.1. AOC1 codes for a histamine-degrading enzyme diamine oxidase. The encoded protein is highly expressed in mature upper villus cells of the intestinal mucosa.
Synonyms: Anti-ABP1; Anti-AOC1; Anti-Amiloride binding protein 1 (amine oxidase (copper-containing)); Anti-DAO
Storage: -20C
Application: Anti-AOC1 antibody produced in rabbit has been used in western blotting.
Biochem Physiol Actions: AOC1 (amine oxidase, copper containing 1) catalyzes the oxidative deamination of primary amines to the corresponding aldehydes. It breaks down polyamines and histamine. Mutation in the gene causes histamine intolerance due to excess of histamine. Decreased expression of AOC1 might be associated with the risk of migraine, especially in women of Caucasian Spanish origin.
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