AMACR (a-methylacyl-CoA racemase) is a 43,304 daltons auxiliary racemase protein expressed in peroxisomes and mitochondria of human liver and fibroblasts. It consists of 382 amino acids, two targeting signals, a mitochondrial sequence at its N terminus, and a peroxisomal sequence at its C terminus.
Synonyms: Anti-alpha-methylacyl-CoA racemase; Anti-RACE
MDL Number: MFCD04118399
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: AMACR (a-methylacyl-CoA racemase) plays a crucial role in the fatty acid metabolism. It mediates the peroxisomal ß-oxidative breakdown of (2R)-pristanic acid and the (25R)-isomer of C(27) bile acid intermediates. Mutation in AMACR gene causes adult-onset sensory motor neuropathy. It causes unnecessary accumulation of specific fatty acids.
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