Tubulin a 1a (TUBA1A) is a member of a-tubulin gene family. It is encoded by the gene mapped to human chromosome 12q13.12. Tubulin a 1a is a vital structural subunit of microtubules that are temporarily expressed in almost all post-mitotic neurons during neuronal development.The encoded protein structure contains core of two ß-sheets enclosed by a-helices. TUBA1A is characterized with an amino-terminal domain with the guanine nucleotide-binding region, an intermediate domain associated with interprotofilament lateral contacts and the modulation of tubulin curvature, and a carboxy-terminal domain that contains region involved in interacting with microtubule-associated proteins (MAPs) and molecular motors, such as kinesins and dynein.
Synonyms: Anti-Tuba1a; Anti-Tubulin, alpha1A
MDL Number: MFCD00145891
Storage: -20C
Application: The antibody has been used in various immunochemical techniques including immunoprecipitation, immunocytochemistry, and immunohistochemistry.
Biochem Physiol Actions: Tubulin is the major building block of microtubules, which is a structural and mobile element in mitosis, intracellular transport, flagellar movement and the cytoskeleton. Monoclonal antibodies recognizing a-tubulin, together with monoclonal antibodies to other tubulin types (a-tubulin isotypes I, II, and III, tyrosine tubulin and acetylated- a -tubulin) provide a specific and useful tool in studying the intracellular distribution of tubulin, and the static and dynamic aspects of the cytoskeleton. In addition, the various tubulin forms have been implicated in cancerous processes and are thus suggested as potential targets for cancer therapy.