Synonyms: Anti-Alkylated DNA repair protein alkB homolog 5
Storage: -20C
Application: Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Western Blotting (1 paper)
Biochem Physiol Actions: ALKBH5 (Alkylation repair homolog 5) is a 2-oxoglutarate (2OG) and ferrous iron-dependent nucleic acid oxygenase (NAOX) belonging to the AlkB family of dioxygenase. It oxidizes the reversible reaction for N6-methyladenosine (m6A) to mRNA in vitro and in vivo. The catalytic domain of ALKBH5 shows dimethyl activity for both the single-stranded RNA and DNA. It negatively regulates mRNA export and RNA metabolism as well as the assembly of mRNA processing factors in nuclear speckles through the demethylation activity. It has been reported that the ALKBH5 expression is upregulated during hypoxia and involved in spermatogenesis.
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