Aldehyde dehydrogenase 18 family member A1 (ALDH18A1) is localized to the mitochondrial inner membrane. It is an ATP- and NADPH-dependent bifunctional enzyme. The gene encoding this protein is present on chromosome 10.
Synonyms: Anti-Delta1-pyrroline-5-carboxylate synthetase antibody produced in rabbit; Anti-Aldehyde dehydrogenase 18 family member A1 antibody produced in rabbit; Anti-P5CS antibody produced in rabbit
Storage: -20C
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Biochem Physiol Actions: Aldehyde dehydrogenase 18 family member A1 (ALDH18A1) catalyzes the reduction of glutamate to ?1-pyrroline-5-carboxylate which is a critical step in the de-novo biosynthesis of proline, arginine and ornithine. It is a bifunctional enzyme having both ?-glutamyl kinase (?-GK) and ?-glutamyl phosphate reductase (?-GPR) activities. The enzyme undergoes alternative splicing to give rise to two isoforms which differ by a two-amino acid insert at the N-terminus of the ?-glutamyl kinase active site. The short isoform is highly active in the gut and it takes part in arginine biosynthesis. The long isoform is involved in the synthesis of proline from glutamate and is expressed in many tissues.
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