AKAP12 (A-kinase anchoring protein 12) is a scaffold protein, and is also called gravin in humans. It has a wide range of tissue expression. Its subcellular distribution depends upon its isoform, which are three in number- a, ß and ?. It has a molecular weight of 300kDa.
Synonyms: Anti-A-kinase anchor protein 12 antibody produced in rabbit; Anti-A-kinase anchor protein 250 kDa antibody produced in rabbit; Anti-AKAP 250 antibody produced in rabbit; Anti-Myasthenia gravis autoantigen gravin antibody produced in rabbit
MDL Number: MFCD08705585
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: AKAP12 (A-kinase anchoring protein 12) interacts with the RII subunit of protein kinase A (PKA), and also interacts with PKC, phosphodiesterase 4D, Ca2+/calmodulin, and the ß2-adrenergic receptor. Thus, it has multiple essential roles in cellular processes. It sequesters Src protein to caveolin-rich lipid rafts, and thus, prevents the interaction of Src with FAK-associated adhesion and signaling complexes. Therefore, it inhibits the movement of tumor cells.
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