The gene AIMP1 (aminoacyl tRNA synthase complex-interacting multifunctional protein 1) is mapped to human chromosome 4q24. It is also popularly called as EMAP2 (endothelial monocyte-activating polypeptide 2). AIMP1 is widely and constitutively expressed.
Synonyms: Anti-Multisynthetase complex auxiliary component p43; Anti-SCYE1 antibody produced in rabbit
Storage: -20C
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Biochem Physiol Actions: Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1) is an apoptosis-induced cytokine. AIMP1 function as an anti-angiogenic agent through inhibition of hypoxia-inducible factor 1a (HIF-1a). AIMP1 associates with a component of the proteasome degradation pathway, PSMA7 (Proteasome subunit a type-7). This interaction causes degradation of HIF-1a and subsequent inhibition of angiogenesis in endothelial cells. Mutations in AIMP1 are associated with Pelizaeus-Merzbacher-like disease. The precursor of AIMP1 interacts with cytoplasmic arginyl-tRNA synthetase and assists in aminoacylation.
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