Ahr (Aryl hydrocarbon receptor) is a helix-loop-helix transcription factor, and a heterodimeric protein, which is a member of the helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) family of transcription factors. It can be activated by various natural and synthetic molecules. It is located in the cytoplasm and is present in a complex with chaperone proteins such as HSP90 (heat shock protein 90), XAP2 (X-associated protein 2 ) and p23 (cochaperone for the Hsp90). It is located on human chromosome 7p211.
Synonyms: Anti-aryl hydrocarbon receptor; Anti-bHLHe76
MDL Number: MFCD00802740
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: The Ahr helps in the inhibitory effects of 2-(4-hydroxy-3-methoxyphenyl)-benzothiazole (YL-109) on development and invasion of MDA-MB-231 (breast adenocarcinoma cell line) by upregulation of Hsp70-interacting protein (CHIP). It regulates invasiveness and metastasis of breast cancer cells. It mediates various biological responses to extensive environmental pollutants.
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