AHCTF1 (AT-hook containing transcription factor 1) gene codes for protein ELYS (embryonic large molecule derived from yolk sac). ELYS is a chromatin-binding nucleoporin. The C-terminus of the protein contains an AT-hook (adenine thymine) domain. ELYS is present in the nuclear matrix and is widely expressed in embryonic haematopoietic tissues (foetal liver, spleen, and thymus). The protein has the ability to shuttle between cytoplasm and nucleus.
Synonyms: Anti-AT hook containing transcription factor 1; Anti-ELYS
Storage: -20C
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Biochem Physiol Actions: ELYS (embryonic large molecule derived from yolk sac) is a component of the nuclear pore complex and is primarily associated with post-mitotic assembly of nuclear pore complex. Thus, it is essential for very early embryonic survival. Lack of ELYS alters the localization of lamin B receptor to the inner nuclear membrane. The protein is crucial for correct cell division.
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