Synonyms: Anti-AF4/FMR2 family member 2 antibody produced in rabbit; Anti-FMR2P antibody produced in rabbit; Anti-Fragile X E mental retardation syndrome protein antibody produced in rabbit; Anti-Fragile X mental retardation 2 protein antibody produced in rabbit; Anti-Protein FMR-2 antibody produced in rabbit; Anti-Protein Ox19 antibody produced in rabbit
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: AFF2 (AF4/FMR2 family, member 2) gene, also known as Fragile Mental Retardation 2 gene, encodes an RNA-binding protein belonging to the AF4FMR2 gene family. It may function as a transcriptional regulator. It is found to co-localize with the splicing factor SC35 in nuclear speckles, where splicing factors are assembled and modified. It binds to G-quartet-forming RNA structure and may be involved in alternative splicing regulation. This gene is associated with the folate-sensitive fragile X E locus on chromosome X and mutations in this gene cause Fragile X E syndrome.
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